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In tropical countries around the world, Dengue fever is one of the most common viral diseases spread to humans by mosquitoes. High fever, headache, nose and mouth bleeding, muscle and joints pain, vomiting, rash and diarrhea are the most common Dengue fever symptoms. In critical phase patient can experience hypo-tension, gastrointestinal bleeding and pleural effusion. Typically, people infected with dengue virus are asymptomatic (80%) or only have mild symptoms such as an uncomplicated fever. Others have more severe illness (5%), and in a small proportion it is life-threatening. In the United States, approximately 100 cases of Dengue are reported each year in travelers returning from tropical areas, but they could be more as the asymptomatic forms are not reported. The emergence of Dengue as a major public health problem has been most dramatic in the western hemisphere. Dengue fever has reached epidemic levels in Central America and is threatening the United States.