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If any part of signaling and feedback system is not working, it can cause major disruptions and illness within the body. Primary adrenal insufficiency, also called addison’s disease, affects the levels of both cortisol and aldosterone. It is caused by underactive or damaged adrenal glands. Secondary adrenal insufficiency is the result of a pituitary dysfunction and typically affects only cortisol production.
Occasionally, doctors suggest this test if pituitary disease is a possible cause of adrenal insufficiency (secondary adrenal insufficiency). The test involves checking your blood sugar (blood glucose) and cortisol levels at various intervals after an injection of insulin. In healthy people, glucose levels fall and cortisol levels increase.